研究领域：

张杰教授、博导、国家杰出青年科学基金、国家优秀青年科学基金、教育部新世纪优秀人才、福建省杰出青年基金等获得者。长期从事重大脑疾病比如老年痴呆（AD）、抑郁症、自闭症、术后认知功能障碍等的致病机理和药物开发研究。提出了神经元细胞周期调控紊乱导致AD致病的新机制；并结合计算机模拟，开发多个小分子化合物用于AD防治研究。。同时，鉴定了中国人群新的抑郁致病风险基因MEN1，为抑郁症的诊治提供了新的靶点和方向。至今以第一作者或通讯作者发表论文20余篇，H index为17。近5年张杰教授以通讯作者在国际知名学术期刊（Nature Neuroscience, Neuron, Biological Psychiatry, Cell Reports, PNAS, JNS, JBC，Clinical Cancer Research等）发表多篇论文。先后主持国家省市课题十余项，总额超过1000万。

学习经历：

1997~2001 四川大学生命科学学院学士；

2001~2006中科院生物物理研究所博士；

工作经历：

2006~2011 美国新泽西州立大学博士后-研究助理；

2011~至今 双色球结果  特聘教授；

代表性成果：

1. Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence. Chow HM, Shi Meng, Cheng A, Gao Y, Chen G, Song X, So RWL, Jie Zhang*, Karl Herrup*. Nat Neurosci. 2019 Nov;22(11):1806-1819.

2. Menin Deficiency Leads to Depressive-likeBehaviors in Mice by Modulating Astrocyte-MediatedNeuroinflammation. Lige Leng,Kai Zhuang,Zeyue Liu,Changquan Huang,Yuehong Gao,Guimiao Chen,Hui Lin,Yu Hu,Di Wu,Meng Shi,Wenting Xie,Hao Sun,Zhicheng Shao,Huifang Li,Kunkun Zhang,Wei Mo,Timothy Y. Huang, Maoqiang Xue,Zengqiang Yuan,Xia Zhang,Guojun Bu,Huaxi Xu,Qi Xu,* and Jie Zhang*Neuron, 2018 Nov 7;100(3):551-563.e7

3. Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression. Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang* Cell Reports (2018) 24, 24, 701–712

4. Jiechao Zhou, Hei-Man Chow, Yan Liu, Di Wu, Meng Shi,Jieyin Li, Lei Wen, Yuehong Gao, Guimiao Chen, Kai Zhuang, Hui Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Hao Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, Guojun Bu, Huaxi Xu, Zengqiang Yuan, Karl Herrup,Jie Zhang* CDK5-dependent BAG3 degradation modulates synaptic protein turnover.Biological Psychiatry (Accepted)

5. Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death. Guo D, Xie W, Xiong P, Li H, Wang S, Chen G, Gao Y, Zhou J, Zhang Y, Bu G, Maoqiang Xue*, M, Jie Zhang*Cell Death Dis. 2018 Sep 20;9(10):951. doi: 10.1038/s41419-018-0983-1

6. Wang F, Zhao W, Gao Y, Zhou J, Li H, Zhang G, Guo D, Xie C, Li J, Zhenyu Yin*, Zhang Jie*. CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis. J Exp Clin Cancer Res. 2019 Jul 4;38(1):286.

7. The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death. Jiechao Zhou, Huifang Li, Xiaoping Li, Guanyun Zhang, Yaqiong Niu, Zengqiang Yuan, Karl Herrup, YunWu Zhang, Guojun Bu, Huaxi Xu, Jie Zhang*The Journal of Neuroscience2015 Feb 11;35(6):2624-35

8. CDK5 activator protein p25 preferentially binds and activates GSK3β. Chow HM, Guo D, Zhou JC, Zhang GY, Li HF, Herrup Karl, Zhang Jie*.Proc Natl Acad Sci (USA). 2014 11, 111(45):E4887-95

9. Cyclin dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis. Longlong Cao, Jiechao Zhou,Junrong Zhang,Sijin Wu, Xintao Yang, Xin Zhao, Huifang Li, Ming Luo, Qian Yu, Jianwei Xie, Ping Li, Xiaoqing Hu, Chaohui Zheng, Guojun Bu, Yun-wu Zhang, Huaxi Xu*, Yongliang Yang*, Changming Huang*, Jie Zhang*Clinical Cancer Research2015 Mar 15;21(6):1419-1428

10. Structural Bioinformatics-Based Identification of EGFR Inhibitor Gefitinib as a Putative Lead Compound for BACE. Mingshan Niu, Jin Hu, Sijin Wu, Xiaoe Zhang, Huaxi Xu, Yunwu Zhang, Jie Zhang*, Yongliang Yang *. Chem. Biol. Drug Des. 2014 Jan;83(1):81-88.

11. Tailoring 3,3'-dihydroxyisorenieratene to hydroxystilbene: finding a resveratrol analogue with increased antiproliferation activity and cell selectivity. Kang YF, Yan WJ, Zhou TW, Dai F, Li XZ, Bao XZ, Du YT, Yuan CH, Wang HB, Ren XR, Liu Q, Jin XL, Zhou B*, Zhang Jie*.Chemistry. 2014 Jul 14;20(29):8904-8.  

12. Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase. Zhang Jie*, Li Huifang, Zhou Tingwen, Zhou Jiechao, Herrup Karl. J Biol. Chem. 287(31), 25985-94 (2012). (*Corresponding authors)

13. Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons. Zhang Jie & Herrup K, Cell Cycle 10(8) 1208-14 (2011).

14. Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. Zhang Jie, Huifang Li, Herrup Karl.The Journal of Neuroscience 30, 5219-5228 (2010).

15. Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation. Zhang Jie, Huifang Li, Herrup Karl. J. Biol. Chem. 285(18), 14052-61 (2010).

16. Nuclear localization of Cdk5 is a key determinant in the post-mitotic state of neurons. Zhang Jie, Cicero, S.A., Wang, L., Romito-Digiacomo, R.R., Yang, Y. and Herrup, K, Proc. Nat. Acad. Sci. (USA) 105, 8772-8777 (2008).

17. Cdk5 and the non-catalytic arrest of the neuronal cell cycle. Zhang Jie, Herrup Karl. Cell Cycle 7:3487-90 (2008).

18. Liu Qiang*, Zhang Jie*, Zhu Hua, Qin Chuan, Chen Qi and Zhao Baolu Zhao, Dissecting the signaling pathway of nicotine-mediated Nneuroprotection in amouse Alzheimer disease model. FASEB J. 21(1), 61-73(*Equal contribution) (2007).

19. Zhang Jie, Liu Qiang, Liu Nian-Qing, Li Fu-Liang, Chen Qi, Qin Chuan, Zhu  Hua, Huang Yu-Ying, He Wei, Zhao Bao-Lu, Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis. FASEB J. 20(8), 1212-4 (2006).

主持过的重要课题：

• 国家杰出青年科学基金，阿尔茨海默病的分子机制研究，2020/01-2024/12，400万 (2020-2024)

• 国家自然科学基金 器官衰老与器官退行性变化重大研究计划 重点项目 200万 （2019-2022）

• 国家自然科学基金 促进海峡两岸科技合作基金 重点项目，220万（2020-2023）

• 国家自然科学优秀青年基金 130万

• 国家自然科学基金面上项目：阿尔茨海默病中CDK5对神经元细胞周期紊乱的作用和机制研究

• 国家自然科学基金面上项目：Cdk5 磷酸化Bag3 及其在神经元突触功能和凋亡中的作用与机制研究

• 教育部新世纪优秀人才

• 福建省杰出青年科学基金

• 福建省卫生教育联合攻关计划

• 我校校长基金：团队基因，成长基金

• 国家重点研发计划：遗传和环境因素交互作用下神经环路的沉默与早期AD发病（骨干）

• 国家863项目：活体多尺度结构成像系统与功能识别关键技术研究（骨干）

近期研究成果总结：

张杰教授课题组常年招收助理教授、博士后；同时期望热忱与神经科学基础与转化研究的学生报考张杰教授课题组研究生。