研究领域：

主要从事针对肿瘤基因组的转化医学研究，运用统计学模型从遗传多态性，体细胞变异，表观基因组学和基因表达等多组学数据中寻找与肿瘤分型，预后，靶向治疗敏感性等临床特征有关的决定因子并解释其调控机制；在此基础上建立基于多组学关联的复杂网络模型，应用人工智能方法发现新的肿瘤驱动基因。入选国家高层次人才青年项目，厦门市“双百计划”、厦门市高层次人才专项等。

学习经历：

1996~2000 华东理工大学 本科；

2000~2003 我校 细胞生物学 硕士；

2004~2006 丹麦科技大学 生物信息学 硕士；

2006~2010 丹麦科技大学 系统生物学 博士。

工作经历：

2010.03~2012.03 哈佛癌症中心 博士后；

2012.05~2017.11 双色球结果 副教授；

2017.11~至今    双色球结果 教授；我校健康医疗国家研究院 副院长

2015~2022  挂职担任我校附属第一医院儿内科科研副主任，开展儿科遗传性缺陷筛查和科研支撑工作；

代表性成果：

1. Li Y, Zou L, Li Q, et al. Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer[J]. Nature Medicine, 2010, 16(2):214.

2. Li Q, Seo J H, Stranger B, et al. Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci[J]. Cell, 2013, 152(3):633-41.

3. Lawrenson K, Li Q, Kar S, et al. Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer[J]. Nature Communications, 2015, 6:8234

4. Jintao Guo , Jiankun Huang , Ying Zhou , Yulin Zhou , Liying Yu, Huili Li , Lingyun Hou , Liuwei Zhu , Dandan Ge , Yuanyuan Zeng , Bayasi Guleng* and Qiyuan Li*. Germline and somatic variations influencethe somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population . BMC Genomics,(2018) 19:538

5. Ke Liu , Jintao Guo , Kuai Liu , Peiyang Fan , Yuanyuan Zeng, Chaoqun Xu, Jiaxin Zhong , Qiyuan Li*, Ying Zhou *. Integrative analysis reveals distinct subtypes with therapeutic implications in KRAS-mutant lung adenocarcinoma . EBioMedicine 36 (2018) 196–208

6. Wu J, Zhong T, Zhu Y, Ge D, Lin X, Li Q*. Effects of particulate matter (PM) on childhood asthma exacerbation and control in Xiamen, China. BMC Pediatrics,  (2019) 19:194

7. Li W, Xu C, Guo J, Liu K, Hu Y, Zou Y, Wei Z, Wang Z, Zhou Y, Li Q. "Cis-and Trans-acting Expression Quantitative Trait Loci of Long Non-coding RNA in 2,549 cancers with potential clinical and therapeutic implications." Frontiers in Oncology 10 (2020): 2279.

8. Wu, J, et al. "IRF4 and STAT3 activities are associated with the imbalanced differentiation of T-cells in responses to inhalable particulate matters." Respiratory Research 21.1 (2020): 1-13