研究领域

本课题组致力于卵母细胞发育过程中的分子调控机制和提高卵子质量新方法的研究，近期在Biol Reprod, Reprod BioMed Online, Environ Int., Cell Cycle, Environ Pollut.等国际学术期刊上发表系列研究论文，解析了由多种因素引起的卵子质量下降进而导致不良生殖结局。课题组利用体外卵母细胞显微操作、基因修饰、多组学分析等相关技术，以临床生殖中心样本和特定疾病动物模型为研究对象，聚焦于改善卵母细胞质量和提高辅助生殖成功率，为生殖临床不孕不育的诊治提供理论基础。主要方向包括：

1.卵母细胞减数分裂调控的分子机制；

2.重大疾病对卵母细胞质量的影响机制；

学习经历

2004.03~2007.01 中科院动物所与东北农业大学 博士学位；

2000.09~2003.07 东北农业大学动物繁殖学专业 硕士学位；

1996.09~2000.07 东北农业大学动物科学专业 学士学位；

工作经历

2022.08~至今 双色球结果 教授；

2013.09~2014.09 美国 西奈山我院发育生物学部 访问学者；

2013.08~2022.07 双色球结果 副教授；

2007.03~2013.07 双色球结果 助理教授；

代表性成果

1. Liao B, Liu C, Xie S, Liu Y, Deng Y, He S, Fu X, Fu B, Wang Y, Chen M, Lin Y, Li F, Xie X, Hong X*, Wang H*. Effects of fine particulate matter (PM 2.5 ) on ovarian function and embryo quality in mice, Environ Int. 2020 Feb;135:105338.PMID: 31841806

2. Fu X, Xu L, Fu B, Wei K, Liu Y, Liao B, He S, Wang Y, Chen M, Lin Y, Li F, Hong Z, Huang X, Xu C*, Wang H*. Pachymic acid protects oocyte by improving the ovarian microenvironment in PCOS mice, Biol Reprod. 2020 Oct; 103(5): 1085-1098.PMID: 32776126

3. Zeng Z, Jiang J, Wang X, Wei K, Liang H, Zeng L, Xu Y, Xie S, Meng Z, Yang X, Guo A*, Wang H*. Kaempferol ameliorates in vitro and in vivo postovulatory oocyte aging in mice, Reprod BioMed Online, 2022 Jul 19; PMID: 36280424

承担的重要课题

1. 国家自然科学基金面上项目，32172730，2022-01至2025-12，主持。

2. 科技部重点研发计划课题，2021YFC2700301，2021-12至2024-11，骨干。

3. 国家自然科学基金专项项目，31941006，2020-01至2022-12，骨干。

4. 科技部重点研发计划课题，2017YFD0501900，2017-01至2020-12，骨干。

5. 国家自然科学基金面上项目，31672248，2017-01至2020-12，主持。

6. 我校校长基金（中央高校基本科研业务费），2015至2017，主持。

7. 我校生物学“双一流”建设“学科发展计划”项目，2022至2024，主持。

获奖及荣誉

福建省级高层次人才（C类），2021年；

发表论文列表（通讯作者* ）

1. Zeng Z, Jiang J, Wang X, Wei K, Liang H, Zeng L, Xu Y, Xie S, Meng Z, Yang X, Guo A*, Wang H*. Kaempferol ameliorates in vitro and in vivo postovulatory oocyte aging in mice, Reprod BioMed Online, 2022 Jul 19; PMID: 36280424

2. Wei K, Wang X, Zeng Z, Gu R, Deng S, Jiang J, Xu C, Li W, Wang H*. Perfluorooctane sulfonate affects mouse oocyte maturation in vitro by promoting oxidative stress and apoptosis induced by mitochondrial dysfunction, Ecotoxicol Environ Saf. 2021 Sep; 225(2021)112807. PMID: 34562787

3. Deng S, Xu C, Xu Z, Zhou L, Xie S, Wei K, Jin Y, Zeng Z, Yang X, Tan S*, Wang H*. Perfluorodecanoic acid induces meiotic defects and deterioration of mice oocytes in vitro, Toxicology. 2021 Aug;460:152884. PMID: 34358620

4. Liu Y, He K, Xu Z, Xu C, Zhao S, Luo Y, Sun X, Qi Z*, Wang H*.Thiamethoxam Exposure Induces Endoplasmic Reticulum Stress and Affects Ovarian Function and Oocyte Development in Mice, J Agric Food Chem. 2021 Feb; 69(6):1942-1952. PMID: 33533595

5. Liang H, Bai Y, Wang H*, Yang X*. Identification of LncRNA Prognostic Markers for Ovarian Cancer by Integration of Co-expression and CeRNA Network, Front. Genet. 2021 Feb; 11:566497.PMID: 33664764

6. Xu Y, Xu C, Xu Z, Wang X, Liang H, Zeng Z, Zeng L, Wei K, Deng S, Xie S, Jiang J, Liu Y, Cao Y*, Wang H*. Fbf1 regulates mouse oocyte meiosis by influencing Plk1, Theriogenology. 2021 April; 164:74-83. PMID: 33561696

7. Fu X, Xu L, Fu B, Wei K, Liu Y, Liao B, He S, Wang Y, Chen M, Lin Y, Li F, Hong Z, Huang X, Xu C*, Wang H*. Pachymic acid protects oocyte by improving the ovarian microenvironment in PCOS mice, Biol Reprod. 2020 Oct; 103(5): 1085-1098.PMID: 32776126

8. Liao B, Liu C, Xie S, Liu Y, Deng Y, He S, Fu X, Fu B, Wang Y, Chen M, Lin Y, Li F, Xie X, Hong X*, Wang H*. Effects of fine particulate matter (PM 2.5 ) on ovarian function and embryo quality in mice, Environ Int. 2020Feb;135:105338.PMID: 31841806

9. Lin Y, Zhuang S, Wang Y, Lin S, Hong Z, Liu Y, Xu L, Li F, Xu B, Chen M, He S, Liao B, Fu X, Jiang Z*, Wang H*.The effects of graphene quantum dots on the maturation of mouse oocytes and development of offspring. J Cell Physiol. 2019 Aug; 234(8):13820-13831. PMID: 30644094

10. Li F, Zhou J, Guo A, Liu Y, Zhang F, Xu B, Liu R, Wang Y, Chen M, Lin Y, He S, Liao B, Fu X, Wang H*. Di(n-butyl) phthalate exposure impairs meiotic competence and development of mouse oocyte. Environ Pollut. 2019 Mar; 246:597-607. PMID: 30605815

11. He S, Xu B, Liu Y, Wang Y, Chen M, Xu L, Liao B, Lui R, Li F, Lin Y, Fu X, Fu B, Hong Z, Liu Y, Qi Z*, Wang H*. SKAP2 regulates Arp2/3 complex for actin-mediated asymmetric cytokinesis by interacting with WAVE2 in mouse oocytes. Cell Cycle. 2017 Sep 21:1-10. PMID: 28933599

12. Liu Y, Wang Y, He S, Chen M, Zhang Z, Fu X, Fu B, Liao B, Lin Y, Qi Z*, Wang H*. Protective effects of resveratrol against mancozeb induced apoptosis damage in mouse oocytes. Oncotarget. 2017 Jan 24; 8(4):6233-6245. PMID: 28031523

13. Chen M, Liu Y, Wang Y, Liu R, Xu B, Zhang F, Li F, Xu L, Lin Y, He S, Liao B, Fu X, Wang X, Yang X*, Wang H*. KIF2A regulates the spindle assembly and the metaphase I-anaphase I transition in mouse oocyte. Sci Rep. 2016 Dec; 6:39337. PMID: 27991556

14. Liu Y, Xu B, Liu R, Xu L, Zhang F, Li F, Zhang Z, Wang Y, Chen M, Qi Z*, Wang H*. Methoxychlor exposure induces oxidative stress and affects mouse oocyte meiotic maturation, Mol Reprod Dev. 2016 Sep;83(9):768-779. PMID: 27434785

15. He X, Song Y, Liu R, Liu Y, Zhang F, Zhang Z, Shen Y, Xu L, Chen M, Wang Y, Xu B, Yang X*, Wang H*. Axin-1 Regulates Meiotic Spindle Organization in Mouse Oocytes. PloS One. 2016 Jun 10;11(6):e0157197. PMID: 27284927

16. Shen Y, Song Y, He X, Zhang F, Huang X, Liu Y, Ding L, Xu L, Zhu M, Hu W, Qi Z, Wang H*, Yang X*. Triphenyltin chloride induces spindle microtubule deploy-merization and inhibits meiotic maturation in mouse oocytes, Reprod Fertil Dev. 2014 Oct;26(8):1084-93. PMID: 23981671

17. Liu Y, Huang X, He X, Ding L, Xu L, Shen Y, Zhang F, Zhu M, Qi Z*, Wang H*. Resveratrol Protects Mouse Oocytes from Methylglyoxal-Induced Oxidative Damage, PloS One. 2013 Oct 23;8(10):e77960 PMID: 24194906

18. Huang X, Ding L, Pan R, Ma P, Cheng P, Zhang C, Sheng Y, He X, Qi Z*, Wang H*. WHAMM is required for meiotic spindle migration and asymmetric cytokinesis in mouse oocytes. Histochem Cell Biol. 2013 Apr;139(4):525-34 PMID: 23160625

19. Ding L, Pan R, Huang X, Wang J, Shen Y, Xu L, Zhang Y, Liu Y, He X, Yang X, Qi Z*, Wang H*. Changes in histone acetylation during oocyte meiotic maturation in diabetic mouse. Theriogenology. 2012 Sep ;78(4):784-92. PMID: 22541329